Robbins AS, Siegel RL, Jemal A (2012) Racial disparities in stage-specific colorectal cancer mortality rates from 1985 to 2008. ![]() Med Clin North Am 89:771–793Īlbano JD, Ward E, Jemal A, Anderson R, Cokkinides VE, Murray T et al (2007) Cancer mortality in the United States by education level and race. Polite BN, Dignam JJ, Olopade OI (2005) Colorectal cancer and race: understanding the differences in outcomes between African Americans and whites. CA Cancer J Clin 62:10–29įreeman HP, Alshafie TA (2002) Colorectal carcinoma in poor blacks. Siegel R, Naishadham D, Jemal A (2012) Cancer statistics. Conclusionsįuture studies that integrate clinical, molecular, and treatment-related data are needed for advancing understanding of the racial disparity in CRC survival, especially for those <50 years old. Moreover, we observed that the disparity in survival has worsened over the past 15 years. Among older patients, we observed a modest increase in risk of death among AA men compared with EA but no difference by race between women. Among younger patients (<50 years), AA race was associated with a 1.34 times (95 % CI 1.06–1.71) higher risk of death compared with EA. We observed a significant interaction between race and age on CRC survival ( p = 0.04). Factors associated with survival were evaluated by fitting Cox proportional hazards regression models to generate hazard ratios (HR) and 95 % CI. Kaplan–Meier methods were used to generate median survival time and corresponding 95 % confidence intervals (CI) by race, age, and gender. The study population was comprised of 3,865 advanced pathologically documented colon and rectal adenocarcinoma cases diagnosed between 01 January 1996 and 31 December 2006: 2,673 (69 %) EA and 1,192 (31 %) AA. In the present study, statewide, population-based data from South Carolina Central Cancer Registry are used to investigate the relationship between race and age on advanced-stage CRC survival. African-Americans (AA) have a higher incidence of and lower survival from colorectal cancer (CRC) compared with European Americans (EA).
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